What is an egg donation program?
The egg donation IVF program is an IVF treatment process where a healthy, fertile and young woman’s eggs are used to produce embryos instead of using the couple’s own eggs. The embryos are transferred back to the recipient woman’s uterus. The program consists of two phases. In the first phase, ovarian stimulation is done in a healthy and young woman who has good ovarian function and produces the embryos. During the wait for transfer, we can freeze all the embryos. The second phase is preparing the endometrium of the recipient with medication, check the thickness by transvaginal ultrasound and transfer the healthy embryo back.
What are the indications for egg donation?
The egg donation program is indicated for the following conditions:
- For women who have declining of ovarian function or poor egg quality with multiple IVF failure
- For women in the stage of premature menopause or menopause caused by natural or surgical reasons, or through chemotherapy or radiation
- To avoid a genetic disorder of which the recipient is known to be a carrier
- To treat infertility in women with gonadal dysgenesis (congenital defect of female reproductive organ), for example congenital absence of ovaries, testicular feminization
Benefits of egg donation IVF
One of the main benefits of the egg donation program is its very high IVF success rate. The reason for this high success rate is the good quality of eggs from healthy and young women, which is the most critical factor of success in the IVF program. An egg donor’s young age means that the chance of pregnancy and risk of miscarriage are the same as those of a healthy young woman’s pregnancy no matter what the age of the recipient is.
How many eggs from the donation program do we need to achieve good success in pregnancy?
The average mature egg number of one stimulation cycle from a young donor is 20. Around 60 percent (12) of mature eggs are fertilized successfully. Sixty percent (7) of fertilized eggs will develop into blastocyst stage embryos. We usually transfer only one or two blastocysts at a time. The remainder of the extra embryos will be frozen for future use.
What is the success rate of our egg donation program?
We have an extraordinarily high pregnancy outcome in our oocyte donation program. Understanding pregnancy rate is very important for comparing success between clinics. Clinical pregnancy rate means that we measure pregnancy outcomes by positive fetal heartbeat and eliminate early miscarriages. Our clinical pregnancy rate continues to increase year on year. On the picture, the clinical pregnancy rate in 2014 was 89% and recently in 2015–2016 the clinical pregnancy rate was nearly 95%. We can guarantee your success.
What are the causes of IVF failure in the egg donation program?
There are a few problems that prevent the recipient from successfully becoming pregnant.
- Underdeveloped endometrium lining (endometrial thickness) from previous traumatic procedures, multiple therapeutic abortion by curettage, previous uterine infection
- Immune infertility that inhibits implantation of the embryos
How do we choose the egg donor?
We need to carry out screening tests to ensure that the egg donors are free from infection and have a normal genetic condition. We will also scan the ovaries and conduct some hormone tests to ensure that the ovarian function is good enough to produce enough good eggs for success. These are the tests we conduct on the egg donors:
- Screening test for sexually transmitted diseases: anti-HIV, VDRL, HBs Ag
- Screening for the genetic disorder that is common in Thailand. i.e. Thalassemia
- Blood groups
- Ovarian function and ovarian reserve tests: AMH levels, FSH, LH, estradiol on day two of the period
- Screening transvaginal ultrasound to identify any gynecologic problems that might decrease the response of ovarian stimulation, for example ovarian cyst